Everything You Must Know About AMPK Activators
AMPK is deemed as the regulator that maintains cellular energy homeostasis that is the foundation for proper functioning of the body. Now in mammals, AMPK is regulating the energy balance at both on cellular level by means of sensing ATP/AMP and ATP/ADP ratio levels and whole body level through response to the hormones and the brain.
ATP is actually the most significant energy molecule present in the body. Simply put, this is where cellular function all begins. Now because of the reason that energy is used by cells, ATP breaks down into ADP that actually has got less potential for energy. ADP is then broken down to AMP which has contains the least energy potential among all 3. This is where AMPK steps in, it is sensing the relative ratios of ATP/ADP/AMP and telling the body if it needs more ADP so by that, it maintains proper functioning.
AMPK work on different processes via different mechanisms. This makes sense since AMPK is the master regulator of all functioning cells. The effect that AMPK activation in the body depend on the complicated balance of factors and the signaling pathways. In the end, you are sure to reap plenty of benefits from improved AMPK activation like:
Anti aging – AMPK activation is gradually declining as we are aging. As a matter of fact, many experts believe that one factor that contributes to aging is AMPK. It is promoting cellular renewal and also, the production of new mitochondria.
Anti inflammation – it is interesting to know that AMPK activation helps in decreasing inflammation but this too can be decreased by inflammation.
Anti diabetic – the truth is, AMPK is becoming more and more understood when it comes to its role in diabetes treatment mainly because of the ability it has in enhancing insulin sensitivity.
Basically, there are more and more nutritional products and herbal products/constituents discovered that are very effective in AMPK activator to which some include:
Number 1. AICAR – this is the analog of AMP which is needed in cellular use and storage similar to ATP. Because it is AMP’s analog, AICAR has the capability of stimulating AMPK’s activity directly which can actually boost muscle performance.
Number 2. ALA – in this case, it’s Alpha Lipoic Acid that is known to be an effective antioxidant but it’s a useful AMPK activator too. This has been uncovered to have anti obesity effect and can increase insulin sensitivity.
Number 3. Green tea extract – actually, this was discovered to assist in the activation of AMPK by activating upstream kinase.
Number 4. Berberine – because of its AMPK activation, berberine was discovered to carry the same anti diabetic effects as metformin.